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KMID : 0870520100140020091
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Journal of Korean Academy of Addiction Psychiatry
2010 Volume.14 No. 2 p.91 ~ p.97
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The P300 in Patients with Alcohol Dependence or Pathological Gambling
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Park E-Jin
Shin Kyung-Chul
Choi Yong-Sung
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Abstract
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Objectives：This study aimed to evaluate an auditory and visual event-related potential, the P300, in patients diagnosed with alcohol dependence or pathological gambling.
Methods：Subjects comprised patients with either alcohol dependence (N=24) or pathological gambling (N=24) and normal controls (N=24). To determine the subjects’ topographic auditory and visual event-related P300 potentials, we used the standard “Oddball paradigm” method, measured via the conventional Global Field Power method.
Results：In patients with alcohol dependence or pathological gambling, the amplitudes of auditory and visual event-related
P300s were significantly lower than those of normal controls (p<0.01). The auditory P300 amplitude and latency revealed
no significant differences between the alcohol dependence and pathological gambling patients. In pathological gambling patients, the visual P300 latencies were significantly later at Fz, Cz, and Pz than they were in alcohol dependence patients (p<0.01).
Conclusion： These results suggest patients with alcohol dependence or pathological gambling have brain dysfunctions with certain neurophysiological aspects. Visual P300 latencies at Fz, Cz, and Pz occurred significantly later in pathological gambling patients than in alcohol dependence patients, suggesting that pathological gambling patients may have greater cognitive function impairment than alcohol dependence patients have.
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KEYWORD
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P300, Event-related potential, Alcohol dependence, Pathological gambling
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